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Partner name:
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Ludwig Institute for Cancer Research
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Short name:
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LICR - UPP
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Country:
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Sweden
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Role:
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CR (contractor)
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The aim of the studies at the Ludwig Institute in Uppsala is to elucidate the signaling
pathways downstream of the receptors for platelet-derived growth factor (PDGF) and
transforming growth factor-beta (TGF-beta) and thereby identify targets for drug
discovery, which can be used to develop signal transduction antagonists; the usefulness
of such antagonists will be explored in animal models and patient studies.
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Name
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Title
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Sex
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Relevant Expertise
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Carl-Henrik Heldin
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PROF |
M
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Signal transduction by PDGF and TGF-beta
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Ulf Hellman
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PROF |
M
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Mass spectrometry
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Arne Östman
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PROF |
M
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Translational research on PDGF antagonists
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Rainer Heuchel
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DR
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M
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Mouse genetic models
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Marene Landström
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DR
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F
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Apoptotic signaling
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Serhiy Souchelnytksyi
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DR
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M
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TGF-beta signaling, proteomics
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Aris Moustakas
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DR
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M
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TGF-beta signaling; microarrys
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Johan Ericsson
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DR
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M
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Posttranslational modifications of transcription factors
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Pietras K, Rubin K,Sjöblom T, Buchdunger E, Sjöquist M, Heldin C-H, and Östman A.
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect
of chemotherapy. Cancer Research 62: 5476-5484, 2002
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Edlund S, Bu S, Schuster N, Aspenström P, Heuchel R, Heldin N-H, ten Dijke P, Heldin
C-H, and Landström M. Transforming growth factor-beta1-induced apoptosis of prostate
cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase
1 and mitogen-activated protein kinase kinase 3. Molecular Biology of the Cell 14:
529-544, 2003
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Kanamoto T, Hellman U, Heldin C-H, and Souchelnytskyi S. Functional proteomics of
transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target
of TGF-beta-dependent regulation of DNA repair. EMBO Journal 21: 1219-1230, 2002
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Kurisaki A, Kose S, Yoneda Y, Heldin C-H, and Moustakas A. Transforming growth factor-beta
induces nuclear import of Smad3 in an importin-beta1- and Ran-dependent manner.
Molecular Biology of the Cell 12: 1079-1091, 2001
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Grönroos E, Hellman U, Heldin C-H, and Ericsson J. Control of Smad7 stability by
competition between acetylation and ubiquitination. Molecular Cell 10: 483-493,
2002
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UPCOMING EVENT
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OECI week |
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OECI Week (WG workshops; Scientific Conference and General Assembly) –
Budapest, 16 to 18 June 2010.
read more..
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