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Partner name:
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Fondazione Piemontese per la Ricerca sul Cancro - ONLUS
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Short name:
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IRCC
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Country:
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Italy
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Role:
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CR (contractor) - Scientific coordinator
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The Fondazione Piemontese per la Ricerca sul Cancro - ONLUS (Piedmontese Foundation
for Cancer Research) is a private-non-profit organization aimed at promoting and
conducting, directly or indirectly, research in both experimental oncology and clinical
oncology, as well as the development of new diagnostic and therapeutic tools useful
for cure of the disease. Through its partner IRCCSpA, the FPRC supports and runs
a comprehensive cancer centre named "Institute for Cancer Research and Treatment"
(IRCC) located in Italy at Candiolo, Turin. Cancer research activities at the Institute
are carried out in affiliation with the University of Turin Medical School. Prof.
Paolo M. Comoglio is the Scientific Director of the Foundation and of the Institute.
Over the last few years, studies at the IRCC on action mechanisms of the Met and
Ron tyrosine kinase receptors have given a definition to the concept "invasive growth,"
a genetic program of cell migration and organization that is essential during organogenesis
and angiogenesis, and is pathologically activated when a tumour acquires an invasive-metastatic
phenotype. IRCC researchers have also discovered and characterized plexins, a family
of related genes, and is studying their role in the genesis of metastasis. Finally,
functional genomics approaches including DNA microarray and gene trapping allowed
initial elucidation of the invasive growth genetic program. IRCC will be the Scientific
Coordinator of TRANSFOG and of its workpackage 4 (systematic gene functional analysis).
To achieve optimal efficacy it the coordination effort, the PI's outstanding expertise
in the field of molecular oncology will be further supported by the specific functional
oncogenomics competences of Dr. Enzo Medico.
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Personnel
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Title
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Relevant Expertise
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Sex
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Paolo M. Comoglio
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Prof
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Scatter Factor-driven invasive growth
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M
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Enzo Medico
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Dr
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Functional genomics
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M
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Federico Bussolino
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Prof
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In vitro and in vivo angiogenesis
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M
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Silvia Giordano
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Prof
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Signal transduction of the Met-Plexin family of receptors
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F
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Giordano et al., 2002. The semaphorin 4D receptor controls invasive growth by coupling
with Met. Nat Cell Biol. 4:720-4.
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Trusolino L, Comoglio PM. Scatter-factor and semaphorin receptors: cell signalling
for invasive growth. Nat Rev Cancer. 2002 Apr;2(4):289-300. Review.
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Trusolino L, Bertotti A, Comoglio PM. A signaling adapter function for alpha6beta4
integrin in the control of HGF-dependent invasive growth. Cell. 2001 Nov 30;107(5):643-54.
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Medico et al., 2001. A gene trap vector system for identifying transcriptionally
responsive genes. Nat Biotechnol. 19:579-82.
Serini et al., Modeling the early stage of vascular network assembly, EMBO J 2003
(in press)
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UPCOMING EVENT
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OECI week |
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OECI Week (WG workshops; Scientific Conference and General Assembly) –
Budapest, 16 to 18 June 2010.
read more..
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