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Partner name:
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University of Innsbruck, Medical School, Institute of Pathophysiology
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Short name:
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IPP
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Country:
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Austria
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Role:
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CR (contractor)
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Defects in cell cycle and apoptosis regulation are causally implicated in lymphoid
malignancies, and glucocorticoids (GC) as well as non-specific chemotherapeutic
drugs that arrest cell cycle progression and/or induce cell death are used therapeutically.
We propose a functional genomics approach towards identifying critical target genes
involved in these processes. The respective techniques (whole genome expression
profiling, large scale RNAi-based screening with newly developed vectors) will further
be made available to the entire consortium. IPP will also produce spotted oligonucleotide
microarrays, for comparative analysis and for screenings across the Consortium members.
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Name
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Title
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Sex
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Relevant Expertise
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Stephan Geley
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DR
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M
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Tet-regulated siRNA vectors
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Reinhard Kofler
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PROF
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M
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Molecular haematology
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Ausserlechner, Geley, Kofler. 2001. The cell cycle inhibitor p16/INK4A sensitizes
lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels.
J.Biol.Chem. 276:10984-10989.
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Geley S, Tim Hunt. 2001. APC/C-dependent proteolysis of human cyclin A starts at
the beginning of mitosis and is not subject to the spindle assembly checkpoint.
J Cell Biol. 153: 137.
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Tonko, M., R. Kofler. 2001. Gene expression profiles of proliferating versus G1/G0
arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis.
FASEB J. 15:693-699.
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Obexer, Kofler, Helmberg. 2001. Expression profiling of glucocorticoid - treated
T-ALL cell lines: rapid repression of multiple genes involved in RNA-, protein-
and nucleotide synthesis. Oncogene 20:4324.
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Löffler, M., S. Geley, A. Helmberg, and R. Kofler. 1999. c-myc does not prevent
glucocorticoid-induced apoptosis of human leukemic lymphoblasts. Oncogene 18:4626-4631.
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UPCOMING EVENT
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OECI week |
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OECI Week (WG workshops; Scientific Conference and General Assembly) –
Budapest, 16 to 18 June 2010.
read more..
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