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Partner name:
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Agendia BV
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Short name:
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Agendia
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Country:
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The Netherlands
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Role:
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CR (contractor)
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Agendia is a SME that identifies gene expression signatures that are of diagnostic
and prognostic value for the treatment of cancer.
The founders of Agendia (R. Bernards and L. van 't Veer) identified the first prognostic
gene expression signature in breast cancer (see Nature 415, 530-536 (2002) and New
England J. Med. 347, 1999-2009 (2002)). Agendia will perform gene expression analysis
using DNA microarrays on several human tumour series including further studies on
breast cancer, melanoma, lymphoma and colon cancer. Using supervised classification
and leave-one-out cross validation procedures, gene expression signatures are obtained
that predict disease outcome in these forms of cancer. Genes that are part of such
prognostic signatures are candidate targets for drug development.
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Name
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Title
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Sex
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Relevant Expertise
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Laura van 't Veer
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DR
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F
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Gene expression profiling of cancer
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Guido Brink
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MR
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M
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DNA microarray analysis (technical)
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Arno Floore
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MR
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M
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DNA microarray analysis (technical)
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van de Vijver, M.J., He, Y.D., van ’t Veer, L.J., Dai, H., A M Hart, A.A.M., Voskuil,
D., Schreiber, G.J., Peterse, J.L., Roberts, C., Marton, M.J., Parrish, M., Atsma,
D., Witteveen, A., Glas, A., Delahaye, L., van der Velde, T., Bartelink, H., Rodenhuis,
S., Rutgers,E. Th., Friend, S.H. and Bernards, R.. (2002). A gene expression signature
as a predictor of survival in breast cancer. New England J. Med. 347, 1999-2009.
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van ’t Veer, L.J., Dai, H., van de Vijver, M.J., He, Y.D., Hart, A. A. M., Mao,
M., Peterse, H.L., van der Kooy, K., Marton, M. J., Witteveen, A.T., Schreiber,
G. J., Kerkhoven, R. M., Roberts, C., Linsley, P. S., Bernards, R., and Friend,
S. H. (2002). Gene expression profiling predicts clinical outcome of breast cancer.
Nature 415, 530-536.
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UPCOMING EVENT
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OECI week |
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OECI Week (WG workshops; Scientific Conference and General Assembly) –
Budapest, 16 to 18 June 2010.
read more..
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